RESEARCH TRIANGLE PARK, N.C., Nov. 17 /PRNewswire/ -- Cigarette smokers struggling to end their addiction may be able to use Zyban® (bupropion hydrochloride) Sustained-Release Tablets as part of a comprehensive program to help them ``ease into'' the quit

``With Zyban, smokers keep smoking for up two weeks while they get ready to quit,'' said Sharon Sharo, director of Zyban Marketing at Glaxo Wellcome Inc. ``It may be important for smokers who want to quit to know that, with Zyban, they don't have to stop smoking all at once.'' The ad explains that smokers set a date to stop smoking during the second week of taking Zyban, and that most people take Zyban for at least 7 to 12 weeks. The campaign features a one-minute television spot, titled ``Winners,'' in which smokers are depicted as ``being in the fight of their lives.'' Zyban is highlighted as giving smokers ``a fighting chance to win,'' and concludes that by using Zyban, ``You don't have to quit all at once.'' The ad notes Zyban doesn't work for everyone. The ad also notes Zyban is a prescription medicine that is different from nicotine replacements. The ad's narration continues, `` ... So you don't have to stop smoking all at once. As Zyban reduces your cravings ... you feel like smoking less and less ... until you're ready to stop completely. Because you're ready to win.'' When samples of Zyban are dispensed in the healthcare provider's office or when the initial prescription of Zyban is filled at the pharmacy, the smoker also receives the Zyban Advantage Plan which includes a medication booklet, program guide, patient questionnaire and a quit preparation workbook. Quitting smokers have three options for enrolling in the Zyban Advantage Plan, and will receive a customized plan to help them quit smoking: Via the Internet: http://www.zyban.com By calling 800-UCAN-QUIT (800-822-6784), or By mailing in the patient questionnaire from the kit. Zyban and the Zyban Advantage Plan are part of a comprehensive smoking cessation program provided by a healthcare professional. In addition to the Zyban Advantage Pack, Zyban is also available in a refill bottle of 60 tablets. The recommended dose of Zyban as an aid to smoking cessation treatment for smokers 18 years of age and older is one 150 mg tablet taken once daily for three days, followed by one 150 mg tablet taken twice daily for at least 7-12 weeks. Patients start Zyban before they quit smoking and are advised to set a date to stop smoking during the second week of therapy to allow Zyban to reach adequate blood levels. Zyban is not for everyone. The most common side effects associated with Zyban are dry mouth and insomnia. These side effects are mild and often disappear in a few weeks. The use of Zyban is also associated with a dose-dependent risk of seizure. Therefore, higher than recommended doses should not be used and Zyban should not be used in people who are taking other medications containing bupropion (i.e. Wellbutrin®, or Wellbutrin SR®). Zyban also should not be used in patients who have or have had a seizure disorder or eating disorder. It also should not be used in people who are taking a monoamine oxidase inhibitor (MAOI). It is important that patients tell their healthcare professionals about all medicines -- prescription and over-the-counter -- they are taking or plan to take. Glaxo Wellcome Inc., a subsidiary of London-based Glaxo Wellcome plc, is a leading research-based pharmaceutical company located in Research Triangle Park, N.C.

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